the only game where i could play inverted is the Sly Cooper series and timesplitters. other than that no mainly because its counter-intuitave and often times im more focused on turnning the right way rather than focusing on whats in the game more often then not getting me killed or forcing me to continue from a checkpoint
Just started inverting the Y axis yesterday while being a self-proclaimed assassin, despite the fact that I suck dick at snipers. It took a few minutes to get used to, but it just doesn't do it for me. It seems like something that would be easier to use to your advantage on a console game, rather than a pc game.
Though, it might just be because I'm moving too much. I'm advancing with my team instead of just taking a team-neutral sniper tower and camping there. So, I will continue this.