Akira gets my vote on this. It paved the way for modern anime as we know it, as well as served as one of the Wachowski Brothers' main inspirations for The Matrix Trilogy. Awesome story, fast-paced action, bits of dark humor, and even some characters that you can (in a weird way) identify with, Akira is a true classic.
And Huey's running a movie tourney, which started way back in March (?). Lady and the Tramp, I think, just happened to get paired with Akira from past wins. And so it is a sad day for the Lady and the Tramp.