I like the non-nuclear post apocalyptic world for a change (I have a thing for abandoned, nature-overrun cities). At first glance it looks like something I can really get into (note that I've only seen the E3 gameplay footage so far). It has the same potential that Uncharted did, but unfortunately, it looks like it's gonna have the same problem Uncharted did too: guns/combat. Now this really is just my personal opinion, but is it really so much to ask for a beautiful looking survival game without shitty gunplay and fight scenes. Uncharted would've been just as great to me as a puzzle/exploration game and I think Last of Us would be too. This is the kind of game that I intentionally set on Easy so that I can take my time and enjoy the environments and story.
Uncharted was bearable and had few enough fighting segments to make it enjoyable overall (enjoyable enough to buy 2 and 3 too). Last of Us looks promising as long as it has similar trade-offs. The only thing that really worries me about it is that little girl. Escort missions are a deal-breaker (WILL NOT BUY).
Edit:
Ok, so I watched another trailer, and apparently it is zombie and combat focused survival.