Currently stuck on 3 or so puzzles in La Mulana.
1 - Unlocking the Twin Labyrinths; aka clearing that cursed fog so you can actually explore it proper. I can explore the middle section somewhat (found one of the Grail tablets, beat one of its two midbosses) if entering from the Inferno Cavern, but I think the solution is via dropping down from Ellmac's room and you need the Twin Statue to do so. Which leads directly to...
2 - How do I even GET the Twin Statue? There's two large statues in the Labyrinth that you use your Flare Gun on, that much I've solved, but ... what? There's also a statue in the Inferno Cavern with a hint of "Turn left and swing your weapon; turn right and swing your weapon" (with a reference to the twins). I think that's related, but....
3 - Solving the four Eden puzzles. Rather than just opening four treasure chests, you now have to explore the Temple of Moonlight and find/scan four specific locations to reveal four pedestals needed to open them with. I've found two. I think my remaining two clues are "stand before a face of the highest rank" (?) and "beneath the dancing man's feet" (I'm sure I heard a reference to the dancing man already, but I don't remember where).
4 - Beating the Anubis miniboss. I'm thinking this is the last obstacle before getting the Serpent Staff (then beating Algon and acquiring the Feather), but ... how? It's nice of them to drop down a ladder so you can escape the room, but he seems invulnerable to attack. (On which note: I've never seen any other enemy, bosses included, glow blue when you hit them for no damage.)
5 - The entrance to the Goddess's Tower. You know, the one from the Surface in the waterfall area. It's covered by rocks now (in fact you can't even tell until you scan it, where your scanner says "the rocks in this area are a lighter shade". What do I blow it up with to reveal the door?)
6 - And getting pretty much anywhere in the Tower of Ruin. There's a weapon box there, but how does it open again?